Total Antioxidant Activity and Insulin Resistance in Iraqi Male Patients with Active Acromegaly: A Case Control Study

Acromegaly is an endocrine hormonal disorder, characterized by progressive somatic deformation, lead to excessive secretion of the growth hormone (GH) and consequent increase of IGF-I (insulin-like growth factor 1), most commonly produced by benign pituitary adenomas. Active acromegaly is characterized by increased levels of free radical and insulin resistance (IR). The aim of the study is to compare the correlate TAA/MDA with (IR) and the correlate of GH/IGF-1 with (IR). This study includes 30 male patients with active acromegaly, their ages ranged (30-40) years, and 30 normal healthy males, their ages ranged (30-40) years as a control group. Patients and volunteers with osteoporosis, osteomalesia, cardiovascular disease, renal failure, hypertension alcoholics, DM2 and smokers were excluded from the study. Blood was collected and the sera were separated from attended the National Diabetes Centre /Baghdad during the period from December 2015 to June 2016. Serum of GH, IGF-1, insulin were determined by (ELISA) kits, glucose, MDA TAA catalase enzyme were estimated colorimetric methods, (IR) = glucose × insulin /405 = IR The results show that there were increase significant difference of GH, IGF-1, GH/IGF-1, insulin, glucose, (IR), MDA, between acromegaly patients and control group (p<0.001), and decrease significant difference of TAA, TAA/MDA, catalase, between acromegaly patients and control group (p<0.001) We conclude that, increase levels of GH, IGF-1, GH/IGF-1 leads to increase lipid peroxidation, through increase MDA levels, and increase oxidative stress, through decrease total antioxidant and catalase enzyme activities in patients with active acromegaly, in a result of elevated ROS production. GH has negative effect on the level of TAA; reduce level of TAA leads to elevated ROS. GH and IGF-1 have more effect on (IR) than TAA/MDA. Our recommendation is giving patients with acromegaly antioxidants as a complementary therapy to reduce the incidents of IR.